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The whole-genome methylation profile of esophageal squamous cell carcinoma

ABSTRACT: Both genetic and epigenetic aberrations are linked by intricate crosstalk, and can either individually or in synergy lead to the development of cancer. Accumulating evidence suggests that epigenetic changes such as alterations in DNA methylation play a crucial role in ESCC. We performed a Illumina Infinium HumanMethylation450 BeadChip to examine the global methylation signature of esophageal squamous cell carcinoma of Chinese patients. DNA methylation profiles of esophageal squamous cell carcinoma (4 samples), paired adjacent normal surrounding tissues (4 samples) and normal esophagus mucosa from healthy individuals (4 samples) were generated using Infinium methylation 450K BeadChips from Illumina (Illumina, San Diego, USA).

ORGANISM(S): Homo sapiens

SUBMITTER: xufeng li

PROVIDER: E-GEOD-52826 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis.

Li Xufeng X Zhou Fuyou F Jiang Chunyu C Wang Yinuo Y Lu Yanqiang Y Yang Fei F Wang Nengchao N Yang Haijun H Zheng Yanfang Y Zhang Jiren J

PloS one 20140722 7

DNA methylation is a critical epigenetic mechanism involved in key cellular processes. Its deregulation has been linked to many human cancers including esophageal squamous cell carcinoma (ESCC). This study was designed to explore the whole methylation status of ESCC and to identify potential plasma biomarkers for early diagnosis. We used Infinium Methylation 450k array to analyze ESCC tissues (n = 4), paired normal surrounding tissues (n = 4) and normal mucosa from healthy individuals (n = 4), a ...[more]

PMID: 25050929

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