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Transcription and translation profiling of human HepaRG cells upon hepatocytic differentiation

ABSTRACT: Comparison of transcriptional and translational regulation upon hepatocytic diffentiation by Total RNA and polysome bound RNA profiling.

ORGANISM(S): Homo sapiens

SUBMITTER: Deepak Kolippakkam

PROVIDER: E-MEXP-1082 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells.

Parent Romain R Beretta Laura L

Genome biology 20080125 1

<h4>Background</h4>We investigated the molecular events associated with the differentiation of liver progenitor cells into functional and polarized hepatocytes, using human HepaRG cells that display potent hepatocytic differentiation-inducible properties and share some features with liver progenitor cells.<h4>Results</h4>Profiling of total and of polysome-bound transcripts isolated from HepaRG cells undergoing hepatocytic differentiation was performed. A group of 3,071 probe sets was reproducibl ...[more]

PMID: 18221535

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