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A human integrin-?3 mutation confers major renal developmental defects.

ABSTRACT: Integrin-?3 plays a central role in the interplay of cells, morphogens and ECM, required for proper nephrogenesis, thus adding ITGA3 to the list of CAKUT (congenital anomalies of the kidney and urinary tract)-causing genes. we used renal tissue originally obtained from a patient with an ITGA3 mutation and assessed its gene expression profile as compared to controls

ORGANISM(S): Homo sapiens

SUBMITTER: jasmine jacob

PROVIDER: E-GEOD-54227 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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