Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Schraga Schwartz
PROVIDER: E-GEOD-54365 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schwartz Schraga S Mumbach Maxwell R MR Jovanovic Marko M Wang Tim T Maciag Karolina K Bushkin G Guy GG Mertins Philipp P Ter-Ovanesyan Dmitry D Habib Naomi N Cacchiarelli Davide D Sanjana Neville E NE Freinkman Elizaveta E Pacold Michael E ME Satija Rahul R Mikkelsen Tarjei S TS Hacohen Nir N Zhang Feng F Carr Steven A SA Lander Eric S ES Regev Aviv A
Cell reports 20140626 1
N6-methyladenosine (m6A) is a common modification of mRNA with potential roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins interacting with METTL3, a component of the methyltransferase complex, and show that three of them (WTAP, METTL14, and KIAA1429) are required for methylation. Monitoring m6A levels upon WTAP depletion allowed the definition of accurate and near single-nucleotide resolution methylation maps and their classification into WTAP-dependent and ...[more]