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The pyruvate-tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Yersinia pseudotuberculosis

SUBMITTER: Ann Heroven

PROVIDER: E-GEOD-54547 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The pyruvate-tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis.

Bücker René R Heroven Ann Kathrin AK Becker Judith J Dersch Petra P Wittmann Christoph C

The Journal of biological chemistry 20140827 43

Despite our increasing knowledge of the specific pathogenicity factors in bacteria, the contribution of metabolic processes to virulence is largely unknown. Here, we elucidate a tight connection between pathogenicity and core metabolism in the enteric pathogen Yersinia pseudotuberculosis by integrated transcriptome and [(13)C]fluxome analysis of the wild type and virulence-regulator mutants. During aerobic growth on glucose, Y. pseudotuberculosis reveals an unusual flux distribution with a high ...[more]

PMID: 25164818

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