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Combinatorial flexibility of cytokine during Human T helper cells differentiation

ABSTRACT: Transcriptional analysis of human T cells differentiated in 4 T Helper context ( Th0, Th1, Th2 and Th17) in the presence or not of Interferon alpha We analyzed the transcriptomic profiles of 4 human naives T cells diferentiated in Th0, Th1, Th2 and Th17 in the presence or not of Interferon Alpha. Microarray analyses were performed in 2 time points : 1/ after Day 5 of polarization (= Day5); 2/ after Day 5+ four hours of re-stimulation (=Day 5+ 4H restim) in 3 different donors.

ORGANISM(S): Homo sapiens

SUBMITTER: Maxime Touzot

PROVIDER: E-GEOD-54627 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Combinatorial flexibility of cytokine function during human T helper cell differentiation.

Touzot Maxime M Grandclaudon Maximilien M Cappuccio Antonio A Satoh Takeshi T Martinez-Cingolani Carolina C Servant Nicolas N Manel Nicolas N Soumelis Vassili V

Nature communications 20140528

In an inflammatory microenvironment, multiple cytokines may act on the same target cell, creating the possibility for combinatorial interactions. How these may influence the system-level function of a given cytokine is unknown. Here we show that a single cytokine, interferon (IFN)-alpha, can generate multiple transcriptional signatures, including distinct functional modules of variable flexibility, when acting in four cytokine environments driving distinct T helper cell differentiation programs ...[more]

PMID: 24865484

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