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Cooperativity and Equilibrium with FOXA1 Define Androgen Receptor Transcriptional Program

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Hong-Jian Jin

PROVIDER: E-GEOD-55007 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program.

Jin Hong-Jian HJ Zhao Jonathan C JC Wu Longtao L Kim Jung J Yu Jindan J

Nature communications 20140530

The pioneering factor FOXA1 opens chromatin to facilitate androgen receptor (AR) binding to prostate-specific genes. How FOXA1 controls the AR cistrome, however, is incompletely understood. Here we show that AR directly binds chromatin through the androgen response elements (AREs). FOXA1 is not required for AR-chromatin interaction, but instrumental in recruiting AR to low-affinity half-AREs by opening local chromatin around adjacent FKHD sites. Too much FOXA1 creates excessive open chromatin re ...[more]

PMID: 24875621

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