Expression data from skin biopsies in pateints with systemic sclerosis treated with anti-TGF-beta, fresolimumab
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ABSTRACT: Systemic sclerosis is associated with skin fibrosis thought mediated by TGFb. This open label clinical trial examines the effect of TGFb inhibition on skin gene expression. Patients 1-9 received two doses 1 mg/kg dose of fresolimumab at baseline and 3 weeks; patients 10-19 received a single 5 mg/kg dose Patients with diffuse cutaneous systemic sclerosis within 2 years of first raynauds had skin biopsies before treatment and the 3-4 weeks, 7 weeks and 24 weeks after treatment with fresolimumab
ORGANISM(S): Homo sapiens
SUBMITTER: Robert Lafyatis
PROVIDER: E-GEOD-55036 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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