Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hélène LAPILLONNE
PROVIDER: E-GEOD-55532 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rouzbeh Shaghayegh S Kobari Ladan L Cambot Marie M Mazurier Christelle C Hebert Nicolas N Faussat Anne-Marie AM Durand Charles C Douay Luc L Lapillonne Hélène H
Stem cells (Dayton, Ohio) 20150513 8
While enucleation is a critical step in the terminal differentiation of human red blood cells, the molecular mechanisms underlying this unique process remain unclear. To investigate erythroblast enucleation, we studied the erythroid differentiation of human embryonic stem cells (hESCs), which provide a unique model for deeper understanding of the development and differentiation of multiple cell types. First, using a two-step protocol, we demonstrated that terminal erythroid differentiation from ...[more]