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Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

ABSTRACT: Gene expression analysis of purified hematopoietic stem and progenitor cells isolated from low to intermediate risk MDS patients and age-matched normal healthy controls. Analysis of lineage associated genes and PCA clustering of populations

ORGANISM(S): Homo sapiens

SUBMITTER: Petter Woll 

PROVIDER: E-GEOD-55689 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Woll Petter S PS   Kjällquist Una U   Chowdhury Onima O   Doolittle Helen H   Wedge David C DC   Thongjuea Supat S   Erlandsson Rikard R   Ngara Mtakai M   Anderson Kristina K   Deng Qiaolin Q   Mead Adam J AJ   Stenson Laura L   Giustacchini Alice A   Duarte Sara S   Giannoulatou Eleni E   Taylor Stephen S   Karimi Mohsen M   Scharenberg Christian C   Mortera-Blanco Teresa T   Macaulay Iain C IC   Clark Sally-Ann SA   Dybedal Ingunn I   Josefsen Dag D   Fenaux Pierre P   Hokland Peter P   Holm Mette S MS   Cazzola Mario M   Malcovati Luca L   Tauro Sudhir S   Bowen David D   Boultwood Jacqueline J   Pellagatti Andrea A   Pimanda John E JE   Unnikrishnan Ashwin A   Vyas Paresh P   Göhring Gudrun G   Schlegelberger Brigitte B   Tobiasson Magnus M   Kvalheim Gunnar G   Constantinescu Stefan N SN   Nerlov Claus C   Nilsson Lars L   Campbell Peter J PJ   Sandberg Rickard R   Papaemmanuil Elli E   Hellström-Lindberg Eva E   Linnarsson Sten S   Jacobsen Sten Eirik W SE  

Cancer cell 20140515 6

Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establish  ...[more]

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