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Unknown,Transcriptomics,Genomics,Proteomics

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Characterization of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows a strong conservation of involved transcription factors

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Linda Rieswijk

PROVIDER: E-GEOD-38124 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks.

Rieswijk Linda L Lizarraga Daneida D Brauers Karen J J KJ Kleinjans Jos C S JC van Delft Joost H M JH

Mutagenesis 20131126 1

The toxic mechanisms of cisplatin have been frequently studied in many species and in vitro cell models. The Netherlands Toxicogenomics Centre focuses on developing in vitro alternatives using genomics technologies for animal-based assays on, e.g. genotoxic hazards. Models such as human hepatocellular carcinoma cell line (HepG2) cells, mouse primary hepatocytes (PMH) and mouse embryonic stem cells (mESC) are used. Our aim was to identify possibly robust conserved mechanisms between these models ...[more]

PMID: 24280081

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