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Transcription profiling of rat blood and liver exposed to acetaminophen (APAP)

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE5593: Acetaminophen (APAP) Rat Blood Training Gene Expression Data Set; GSE5594: Acetaminophen (APAP) Rat Blood Test Gene Expression Data Set; GSE5595: Acetaminophen (APAP) Rat Liver Test Gene Expression Data Set; The Supplementary files (appended below) contain the mapping for the decoding of blinded samples. Experiment Overall Design: Refer to individual Series

ORGANISM(S): Rattus norvegicus

SUBMITTER: Pierre Robert Bushel

PROVIDER: E-GEOD-5652 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Blood gene expression signatures predict exposure levels.

Bushel P R PR Heinloth A N AN Li J J Huang L L Chou J W JW Boorman G A GA Malarkey D E DE Houle C D CD Ward S M SM Wilson R E RE Fannin R D RD Russo M W MW Watkins P B PB Tennant R W RW Paules R S RS

Proceedings of the National Academy of Sciences of the United States of America 20071102 46

To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP) intoxication, the leading cause of liver failure in the U.S. We hypothesized that gene expression patterns derived from blood cells would provide useful indicators of acute exposure levels. To test this hypothesis, we used a blood gene expression data set from rats exposed to APAP to train classifiers ...[more]

PMID: 17984051

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