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Genome-wide profiling of the DNA methylation landscape in primary and matastatic breast cancer types [468LN and 468PT]

ABSTRACT: Whole genome bisulphite sequencing of 2 human breast cancer cell lines representing a breast primary tumor and a matched lymph node metastasis. Sequencing of bisulfite converted DNA of cancer cell line samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Gómez

PROVIDER: E-GEOD-56763 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition.

Carmona F Javier FJ Davalos Veronica V Vidal Enrique E Gomez Antonio A Heyn Holger H Hashimoto Yutaka Y Vizoso Miguel M Martinez-Cardus Anna A Sayols Sergi S Ferreira Humberto J HJ Sánchez-Mut Jose V JV Morán Sebastián S Margelí Mireia M Castella Eva E Berdasco Maria M Stefansson Olafur A OA Eyfjord Jorunn E JE Gonzalez-Suarez Eva E Dopazo Joaquín J Orozco Modesto M Gut Ivo G IG Esteller Manel M

Cancer research 20140808 19

Epithelial-to-mesenchymal transition (EMT) is a plastic process in which fully differentiated epithelial cells are converted into poorly differentiated, migratory and invasive mesenchymal cells, and it has been related to the metastasis potential of tumors. This is a reversible process and cells can also eventually undergo mesenchymal-to-epithelial transition. The existence of a dynamic EMT process suggests the involvement of epigenetic shifts in the phenotype. Herein, we obtained the DNA methyl ...[more]

PMID: 25106427

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