Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Scot Matkovich
PROVIDER: E-GEOD-56890 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hu Yuanxin Y Matkovich Scot J SJ Hecker Peter A PA Zhang Yan Y Edwards John R JR Dorn Gerald W GW
Proceedings of the National Academy of Sciences of the United States of America 20121112 48
Cardiac stress responses are driven by an evolutionarily conserved gene expression program comprising dozens of microRNAs and hundreds of mRNAs. Functionalities of different individual microRNAs are being studied, but the overall purpose of interactions between stress-regulated microRNAs and mRNAs and potentially distinct roles for microRNA-mediated epigenetic and conventional transcriptional genetic reprogramming of the stressed heart are unknown. Here we used deep sequencing to interrogate mic ...[more]