Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Scot Matkovich
PROVIDER: E-GEOD-62689 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Song Moshi M Matkovich Scot J SJ Zhang Yan Y Hammer Daniel J DJ Dorn Gerald W GW
Science signaling 20150421 373
Cell growth is orchestrated by changes in gene expression that respond to developmental and environmental cues. Among the signaling pathways that direct growth are enzymes of the protein kinase C (PKC) family, which are ubiquitous proteins belonging to three distinct subclasses: conventional PKCs, novel PKCs, and atypical PKCs. Functional overlap makes determining the physiological actions of different PKC isoforms difficult. We showed that two novel PKC isoforms, PKCδ and PKCε, redundantly gove ...[more]