Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Uma Shankavaram
PROVIDER: E-GEOD-57091 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Maachani Uday Bhanu UB Kramp Tamalee T Hanson Ryan R Zhao Shuping S Celiku Orieta O Shankavaram Uma U Colombo Riccardo R Caplen Natasha J NJ Camphausen Kevin K Tandle Anita A
Molecular cancer research : MCR 20150226 5
<h4>Unlabelled</h4>To ensure faithful chromosome segregation, cells use the spindle assembly checkpoint (SAC), which can be activated in aneuploid cancer cells. Targeting the components of SAC machinery required for the growth of aneuploid cells may offer a cancer cell-specific therapeutic approach. In this study, the effects of inhibiting Monopolar spindle 1, MPS1 (TTK), an essential SAC kinase, on the radiosensitization of glioblastoma (GBM) cells were analyzed. Clonogenic survival was used to ...[more]