Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Adolfo Ferrando
PROVIDER: E-GEOD-5716 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Palomero Teresa T Sulis Maria Luisa ML Cortina Maria M Real Pedro J PJ Barnes Kelly K Ciofani Maria M Caparros Esther E Buteau Jean J Brown Kristy K Perkins Sherrie L SL Bhagat Govind G Agarwal Archana M AM Basso Giuseppe G Castillo Mireia M Nagase Satoru S Cordon-Cardo Carlos C Parsons Ramon R Zúñiga-Pflücker Juan Carlos JC Dominguez Maria M Ferrando Adolfo A AA
Nature medicine 20070916 10
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and lymphomas (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors, which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been tempered by tumor resistance and the paucity of information on the oncogenic programs regulated by oncogenic NOTCH1. Here we show that NOTCH1 regulates the expression of PTEN (encoding phos ...[more]