Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Christina Marney
PROVIDER: E-GEOD-58379 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vanharanta Sakari S Marney Christina B CB Shu Weiping W Valiente Manuel M Zou Yilong Y Mele Aldo A Darnell Robert B RB Massagué Joan J
eLife 20140604
The mechanisms through which cancer cells lock in altered transcriptional programs in support of metastasis remain largely unknown. Through integrative analysis of clinical breast cancer gene expression datasets, cell line models of breast cancer progression, and mutation data from cancer genome resequencing studies, we identified RNA binding motif protein 47 (RBM47) as a suppressor of breast cancer progression and metastasis. RBM47 inhibited breast cancer re-initiation and growth in experimenta ...[more]