Unknown,Transcriptomics,Genomics,Proteomics

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Flag-RBM47 HITS-CLIP in brain metastatic derivatives of MDA-MB-231

ABSTRACT: Brain metastatic breast cancer cells were subjected to HITS-CLIP to identify the targets of the RNA binding protein RBM47 MDA231-BrM2a is characterized in PMID: 19421193; Related data published together with these data are found in GSE53779 Non-clonal brain metastatic breast cancer cells stably expressing Flag-tagged, wild-type RBM47 under a doxycline-inducible promoter were treated for three days with doxycycline then UV-irradiated and subjected to Flag HITS-CLIP

ORGANISM(S): Homo sapiens

SUBMITTER: Christina Marney 

PROVIDER: E-GEOD-58380 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.

Vanharanta Sakari S   Marney Christina B CB   Shu Weiping W   Valiente Manuel M   Zou Yilong Y   Mele Aldo A   Darnell Robert B RB   Massagué Joan J  

eLife 20140604

The mechanisms through which cancer cells lock in altered transcriptional programs in support of metastasis remain largely unknown. Through integrative analysis of clinical breast cancer gene expression datasets, cell line models of breast cancer progression, and mutation data from cancer genome resequencing studies, we identified RNA binding motif protein 47 (RBM47) as a suppressor of breast cancer progression and metastasis. RBM47 inhibited breast cancer re-initiation and growth in experimenta  ...[more]

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