Ontology highlight
ABSTRACT:
ORGANISM(S): Streptococcus pneumoniae D39
SUBMITTER: Sulman Shafeeq
PROVIDER: E-GEOD-58424 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Smith Claire M CM Sandrini Sara S Datta Sumit S Freestone Primrose P Shafeeq Sulman S Radhakrishnan Priya P Williams Gwyneth G Glenn Sarah M SM Kuipers Oscar P OP Hirst Robert A RA Easton Andrew J AJ Andrew Peter W PW O'Callaghan Christopher C
American journal of respiratory and critical care medicine 20140701 2
<h4>Rationale</h4>Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major respiratory pathogens. Coinfection with RSV and S. pneumoniae is associated with severe and often fatal pneumonia but the molecular basis for this remains unclear.<h4>Objectives</h4>To determine if interaction between RSV and pneumococci enhances pneumococcal virulence.<h4>Methods</h4>We used confocal microscopy and Western blot to identify the receptors involved in direct binding of RSV and pneumococci, t ...[more]