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Genome wide mapping of AR and its associated factors in prostate cancer

ABSTRACT: Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation.We performed ChIP-seq analysis to investigate the role of AR and its associated factors such as coregulators or collaborating factors.In addition, by siRNA mediated knockdown of such factors, changes of AR-binding sites in prostate cancer cells were analyzed. ChIP-sequence analysis of AR and its associated factors in prostate cancer cells

ORGANISM(S): Homo sapiens

SUBMITTER: Ken-ichi Takayama

PROVIDER: E-GEOD-58428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CtBP2 modulates the androgen receptor to promote prostate cancer progression.

Takayama Ken-Ichi K Suzuki Takashi T Fujimura Tetsuya T Urano Tomohiko T Takahashi Satoru S Homma Yukio Y Inoue Satoshi S

Cancer research 20140916 22

The androgen receptor (AR) is the key driver of both early and advanced prostate cancer, making a complete understanding of its regulation important. Here, we report the identification of multiple AR-binding sites in the gene encoding the transcription factor CtBP2 (carboxyl terminal-binding protein), genetic variations of which have been associated with prostate cancer susceptibility. Notably, we found that SNPs in the human CTBP2 gene that were associated with prostate cancer development were ...[more]

PMID: 25228652

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