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Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing

ABSTRACT: We utilized RNA sequencing to expand and better define the molecular entities involved in the transcriptional programming within the eosphagus in eosinophilic esophagitis (EoE) Examination of differentially expressed genes from RNA sequencing data performed on esophageal biopsy specimen from 6 healthy controls and 10 patients with active EoE

ORGANISM(S): Homo sapiens

SUBMITTER: Marc Rothenberg

PROVIDER: E-GEOD-58640 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing.

Sherrill J D JD Kiran K C KC Blanchard C C Stucke E M EM Kemme K A KA Collins M H MH Abonia J P JP Putnam P E PE Mukkada V A VA Kaul A A Kocoshis S A SA Kushner J P JP Plassard A J AJ Karns R A RA Dexheimer P J PJ Aronow B J BJ Rothenberg M E ME

Genes and immunity 20140612 6

Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder of the esophagus that is compounded by genetic predisposition and hypersensitivity to environmental antigens. Using high-density oligonucleotide expression chips, a disease-specific esophageal transcript signature was identified and was shown to be largely reversible with therapy. In an effort to expand the molecular signature of EoE, we performed RNA sequencing on esophageal biopsies from healthy controls and patients with acti ...[more]

PMID: 24920534

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