Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mayte Suarez-Farinas
PROVIDER: E-GEOD-59294 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of allergy and clinical immunology 20141201 6
<h4>Background</h4>Severe atopic dermatitis (AD) has a high unmet need for effective and safe therapeutics. In early-phase trials, dupilumab, a fully human mAb targeting IL-4 receptor α, markedly improved disease activity, but the effect of IL-4/IL-13 blockade on AD at the molecular level has not been characterized.<h4>Objectives</h4>We sought to evaluate dupilumab modulation of the AD molecular signature.<h4>Methods</h4>We performed transcriptomic analyses of pretreatment and posttreatment skin ...[more]