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Striatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntington's disease

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Karine Merienne

PROVIDER: E-GEOD-59572 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice.

Achour Mayada M Le Gras Stéphanie S Keime Céline C Parmentier Frédéric F Lejeune François-Xavier FX Boutillier Anne-Laurence AL Néri Christian C Davidson Irwin I Merienne Karine K

Human molecular genetics 20150317 12

Huntington's disease (HD) is a neurodegenerative disease associated with extensive down-regulation of genes controlling neuronal function, particularly in the striatum. Whether altered epigenetic regulation underlies transcriptional defects in HD is unclear. Integrating RNA-sequencing (RNA-seq) and chromatin-immunoprecipitation followed by massively parallel sequencing (ChIP-seq), we show that down-regulated genes in HD mouse striatum associate with selective decrease in H3K27ac, a mark of activ ...[more]

PMID: 25784504

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