Genomics

Dataset Information

0

A role for Widely Interspaced Zinc finger (WIZ) in retention of the G9a methyltransferase on chromatin


ABSTRACT: G9a and GLP lysine methyltransferases form a heterodimeric complex that is responsible for the bulk of cellular mono- and di-methylation on histone H3 lysine 9 (H3K9me1/me2). Widely Interspaced Zinc finger (WIZ) associates with the G9a/GLP protein complex, but its role in lysine methylation is poorly defined. Here, we show that WIZ regulates global H3K9me2 levels through a mechanism that involves retention of G9a on chromatin. We also show that WIZ-mediated chromatin loss of G9a/GLP results in altered gene expression and protein-protein interactions that are distinguishable from that of using a molecule-induced enzymatic inhibitor towards G9a/GLP – thus providing evidence that the G9a/GLP/WIZ complex has unique functions when bound to chromatin that are independent of the H3K9me2 mark

ORGANISM(S): Homo sapiens

PROVIDER: GSE67317 | GEO | 2015/09/03

SECONDARY ACCESSION(S): PRJNA279892

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2015-09-03 | E-GEOD-67317 | biostudies-arrayexpress
2022-12-02 | GSE191026 | GEO
2016-02-01 | GSE72626 | GEO
2016-03-16 | PXD003466 | Pride
2021-08-05 | PXD024756 | Pride
2015-01-20 | E-GEOD-54412 | biostudies-arrayexpress
2015-07-15 | GSE70914 | GEO
2014-09-25 | E-GEOD-59749 | biostudies-arrayexpress
2023-05-12 | PXD041742 | Pride
2021-03-18 | GSE169103 | GEO