Dataset Information
Ribosome profiling and RNA sequencing of MCF10A cells treated with torin or by serum starvation
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Koos Rooijers
PROVIDER: E-GEOD-59816 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading.
Nature 20160215 7591
Tumour growth and metabolic adaptation may restrict the availability of certain amino acids for protein synthesis. It has recently been shown that certain types of cancer cells depend on glycine, glutamine, leucine and serine metabolism to proliferate and survive. In addition, successful therapies using L-asparaginase-induced asparagine deprivation have been developed for acute lymphoblastic leukaemia. However, a tailored detection system for measuring restrictive amino acids in each tumour is c ...[more]
