Unknown,Transcriptomics,Genomics,Proteomics

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Circulating Dirofilaria immitis microRNAs in dog plasma


ABSTRACT: We report the presence of circulating miRNAs released by the filarial nematode Dirofilaria immitis into the host (Canis familiaris) bloodstream. MiRNA deep-sequencing combined with bioinformatics revealed over 200 mature miRNA sequences of potential nematode origin in Dirofilaria immitis-infected dog plasma in two independent analyses

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Lucienne Tritten 

PROVIDER: E-GEOD-60170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Detection of circulating parasite-derived microRNAs in filarial infections.

Tritten Lucienne L   Burkman Erica E   Moorhead Andrew A   Satti Mohammed M   Geary James J   Mackenzie Charles C   Geary Timothy T  

PLoS neglected tropical diseases 20140717 7


Filarial nematodes cause chronic and profoundly debilitating diseases in both humans and animals. Applications of novel technology are providing unprecedented opportunities to improve diagnosis and our understanding of the molecular basis for host-parasite interactions. As a first step, we investigated the presence of circulating miRNAs released by filarial nematodes into the host bloodstream. miRNA deep-sequencing combined with bioinformatics revealed over 200 mature miRNA sequences of potentia  ...[more]

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