Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: PIN WANG
PROVIDER: E-GEOD-60307 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Liu Yiqi Y Zhang Qian Q Ding Yuanyuan Y Li Xia X Zhao Dezhi D Zhao Kai K Guo Zhenhong Z Cao Xuetao X
Journal of immunology (Baltimore, Md. : 1950) 20150216 6
Histone modifications play critical roles in the regulation of gene expression; however, their roles in the regulation of the innate response remain to be fully investigated. Using transcriptome analysis of mouse immature dendritic cells (DCs) and LPS-induced mature DCs, we identified that Ezh1 was the most upregulated histone methyltransferase during DC maturation. In this study, we investigated the role of Ezh1 in regulating the innate immune response. We found that silencing of Ezh1 significa ...[more]