Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene expression changes upon knockdown of DEK in the U937 cell line

ABSTRACT: Gene expression profiling of U937 cells upon knockdown of the DEK oncogene by two different shRNAs (shDEK14 and shDEK17). The DEK oncogene was knocked down by shRNA to study the changes in gene expression.

ORGANISM(S): Homo sapiens

SUBMITTER: Carl Sanden

PROVIDER: E-GEOD-60732 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.

Sandén Carl C Järvstråt Linnea L Lennartsson Andreas A Brattås Per Ludvik PL Nilsson Björn B Gullberg Urban U

Molecular cancer 20140912

<h4>Background</h4>The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.<h4>Methods</h4>We performed ChIP-seq analysis in the myeloid cell line U937 and coupled it with epigenetic and gene expression analysis to explore the genome-wide binding pattern of DEK and its role in ...[more]

PMID: 25216995

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Dataset Information

Gene expression changes upon knockdown of DEK in the U937 cell line

Publications

The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.

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