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Aggression, cognitive and neurodevelopmental abnormalities associated with disruption of the intellectual disability and histone demethylase gene Kdm5c

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Saurabh Agarwal

PROVIDER: E-GEOD-61036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.

Iwase Shigeki S Brookes Emily E Agarwal Saurabh S Badeaux Aimee I AI Ito Hikaru H Vallianatos Christina N CN Tomassy Giulio Srubek GS Kasza Tomas T Lin Grace G Thompson Andrew A Gu Lei L Kwan Kenneth Y KY Chen Chinfei C Sartor Maureen A MA Egan Brian B Xu Jun J Shi Yang Y

Cell reports 20160121 5

Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl (H3K4me2/3)-specific demethylase, is frequently mutated in X-linked intellectual disability (XLID) patients. Here, we report that disruption of the mouse Kdm5c gene recapitulates adaptive and cognitive abnormalities observed in XLID, including impaired social behavior, memory deficits, and aggression. Kdm5c-knockout brains exhibit abnormal dendritic arbor ...[more]

PMID: 26804915

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