Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Gene expression profiling and genome-wide maps in PDGFB-induced glioma


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Richard Lu 

PROVIDER: E-GEOD-80089 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Malignant gliomas exhibit extensive heterogeneity and poor prognosis. Here we identify mitotic Olig2-expressing cells as tumor-propagating cells in proneural gliomas, elimination of which blocks tumor initiation and progression. Intriguingly, deletion of Olig2 resulted in tumors that grow, albeit at a decelerated rate. Genome occupancy and expression profiling analyses reveal that Olig2 directly activates cell-proliferation machinery to promote tumorigenesis. Olig2 deletion causes a tumor phenot  ...[more]

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