Unknown,Transcriptomics,Genomics,Proteomics

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Primary and adjacent non-malignant tissue samples of 100 HCC patients (mRNA)

ABSTRACT: Genome-wide mRNA expression profiles of 100 primary and matched non-malignant tissues of HCC patients from a Singapore patient cohort. HCC is a hetergenous disease and it is important to understand the underlying molecular mechanisms. Here, we studied the role of microRNAs in HCC by integrating microRNA and gene expression profiles of HCC patients. Profiling of 100 primary and adjacent non-malignant HCC tissue samples on Agilent two-color whole human genome gene expression microarray (design G4112F). All tissues were collected with approvals from the National Cancer Centre, Singapore; the Research Ethics Review Committee; and signed patient informed consent.

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Thurnherr 

PROVIDER: E-GEOD-62043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways.

Thurnherr Thomas T   Mah Way-Champ WC   Lei Zhengdeng Z   Jin Yu Y   Rozen Steven G SG   Lee Caroline G CG  

Scientific reports 20160128

To date, studies of the roles of microRNAs (miRNAs) in hepatocellular carcinoma (HCC) have either focused on specific individual miRNAs and a small number of suspected targets or simply reported a list of differentially expressed miRNAs based on expression profiling. Here, we seek a more in-depth understanding of the roles of miRNAs and their targets in HCC by integrating the miRNA and messenger RNA (mRNA) expression profiles of tumorous and adjacent non-tumorous liver tissues of 100 HCC patient  ...[more]

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