Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Felix Krueger
PROVIDER: E-GEOD-62150 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cambuli Francesco F Murray Alexander A Dean Wendy W Dudzinska Dominika D Krueger Felix F Andrews Simon S Senner Claire E CE Cook Simon J SJ Hemberger Myriam M
Nature communications 20141126
Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription factors or activation of the extracellular signal-regulated kinase 1/2 (Erk1/2) pathway. Here we have interrogated the progression of reprogramming in ES cell models with regulatable Oct4 and Cdx2 transgen ...[more]