Unknown,Transcriptomics,Genomics,Proteomics

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Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Felix Krueger 

PROVIDER: E-GEOD-62150 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast.

Cambuli Francesco F   Murray Alexander A   Dean Wendy W   Dudzinska Dominika D   Krueger Felix F   Andrews Simon S   Senner Claire E CE   Cook Simon J SJ   Hemberger Myriam M  

Nature communications 20141126


Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription factors or activation of the extracellular signal-regulated kinase 1/2 (Erk1/2) pathway. Here we have interrogated the progression of reprogramming in ES cell models with regulatable Oct4 and Cdx2 transgen  ...[more]

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