Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ramesh Shivdasani
PROVIDER: E-GEOD-62909 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cellular and molecular gastroenterology and hepatology 20151101 6
<h4>Background & aims</h4>Intestinal metaplasia (Barrett's esophagus, BE) is the principal risk factor for esophageal adenocarcinoma (EAC). Study of the basis for BE has centered on intestinal factors, but loss of esophageal identity likely also reflects absence of key squamous-cell factors. As few determinants of stratified epithelial cell-specific gene expression are characterized, it is important to identify the necessary transcription factors.<h4>Methods</h4>We tested regional expression of ...[more]