Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: Ales Pecinka
PROVIDER: E-GEOD-63355 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Liu Chun-Hsin CH Finke Andreas A Díaz Mariana M Rozhon Wilfried W Poppenberger Brigitte B Baubec Tuncay T Pecinka Ales A
The Plant cell 20150528 6
DNA damage repair is an essential cellular mechanism that maintains genome stability. Here, we show that the nonmethylable cytidine analog zebularine induces a DNA damage response in Arabidopsis thaliana, independent of changes in DNA methylation. In contrast to genotoxic agents that induce damage in a cell cycle stage-independent manner, zebularine induces damage specifically during strand synthesis in DNA replication. The signaling of this damage is mediated by additive activity of ATAXIA TELA ...[more]