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Yeast Genomic Expression Patterns in Response to glucosylated mycotoxin

ABSTRACT: The evaluation of mycotoxicity about glucosylated mycotoxin using yeast gene expression comparison analysis. Yeast BY4743 derivative PDR5 mutant was used for this study. Samples were normalized with the three replicates per condition. Yeast strain was grown in YPD medium with 80 Î¼M of deoxynivalenol-3-glucoside. The same volume of DMSO was added into control samples.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Tadahiro Suzuki

PROVIDER: E-GEOD-63663 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Low toxicity of deoxynivalenol-3-glucoside in microbial cells.

Suzuki Tadahiro T Iwahashi Yumiko Y

Toxins 20150120 1

Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synthesized by grain uridine diphosphate-glucosyltransferase, and is found worldwide, although information on its toxicity is lacking. Here, we conducted growth tests and DNA microarray analysis to elucidate the characteristics of DON3G. The Saccharomyces cerevisiae PDR5 mutant strain exposed to DON3G d ...[more]

PMID: 25609182

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