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DNA methylation profiles of multiple human tissues

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Horvath

PROVIDER: E-GEOD-64511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The cerebellum ages slowly according to the epigenetic clock.

Horvath Steve S Mah Vei V Lu Ake T AT Woo Jennifer S JS Choi Oi-Wa OW Jasinska Anna J AJ Riancho José A JA Tung Spencer S Coles Natalie S NS Braun Jonathan J Vinters Harry V HV Coles L Stephen LS

Aging 20150501 5

Studies that elucidate why some human tissues age faster than others may shed light on how we age, and ultimately suggest what interventions may be possible. Here we utilize a recent biomarker of aging (referred to as epigenetic clock) to assess the epigenetic ages of up to 30 anatomic sites from supercentenarians (subjects who reached an age of 110 or older) and younger subjects. Using three novel and three published human DNA methylation data sets, we demonstrate that the cerebellum ages more ...[more]

PMID: 26000617

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