Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Adrianus Boon
PROVIDER: E-GEOD-64750 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Boon Adrianus C M AC deBeauchamp Jennifer J Hollmann Anna A Luke Jennifer J Kotb Malak M Rowe Sarah S Finkelstein David D Neale Geoffrey G Lu Lu L Williams Robert W RW Webby Richard J RJ
Journal of virology 20090812 20
Despite the prevalence of H5N1 influenza viruses in global avian populations, comparatively few cases have been diagnosed in humans. Although viral factors almost certainly play a role in limiting human infection and disease, host genetics most likely contribute substantially. To model host factors in the context of influenza virus infection, we determined the lethal dose of a highly pathogenic H5N1 virus (A/Hong Kong/213/03) in C57BL/6J and DBA/2J mice and identified genetic elements associated ...[more]