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Transcriptome analysis of wild type and erythromycin-producing strain of S. erythraea

ABSTRACT: Erythromycin is a medically important antibiotic, biosynthesized by the actinomycete Saccharopolyspora erythraea. We used transcriptomic approach to compare whole genome expression in erythromycin high-producing strain, compared to the wild type S. erythraea strain in four stages of fermentation. 2 strains (3 individual fermentations each), 4 time points --> 24 samples (2 exluded from anaysis, 22 remaining); one color design

ORGANISM(S): Saccharopolyspora erythraea

SUBMITTER: Spela Baebler

PROVIDER: E-GEOD-65007 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea.

Karničar Katarina K Drobnak Igor I Petek Marko M Magdevska Vasilka V Horvat Jaka J Vidmar Robert R Baebler Špela Š Rotter Ana A Jamnik Polona P Fujs Štefan Š Turk Boris B Fonovič Marko M Gruden Kristina K Kosec Gregor G Petković Hrvoje H

Microbial cell factories 20160603

<h4>Background</h4>Omics approaches have significantly increased our understanding of biological systems. However, they have had limited success in explaining the dramatically increased productivity of commercially important natural products by industrial high-producing strains, such as the erythromycin-producing actinomycete Saccharopolyspora erythraea. Further yield increase is of great importance but requires a better understanding of the underlying physiological processes.<h4>Results</h4>To ...[more]

PMID: 27255285

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Transcriptome analysis of wild type and erythromycin-producing strain of S. erythraea

Project description:Erythromycin is a medically important antibiotic, biosynthesized by the actinomycete Saccharopolyspora erythraea. We used transcriptomic approach to compare whole genome expression in erythromycin high-producing strain, compared to the wild type S. erythraea strain in four stages of fermentation.

2016-06-22 | GSE65007 | GEO

Phenotype and expression profile of S. erythraea rifampicin-resistant (rif) mutants affected in erythromycin production

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Project description:Transcriptome analysis of wild type and erythromycin-producing strain of S. erythraea

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