Unknown,Transcriptomics,Genomics,Proteomics

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Expression profiling of breast cancer samples from Institut Curie (Maire cohort) --Affy CDF

ABSTRACT: Transcriptome analysis of 130 breast cancer samples (41 TNBC ; 30 Her2 ; 30 Luminal B and 29 Luminal A), 11 normal breast tissue samples and 14 TNBC cell lines. This dataset contains 178 arrays. 153 arrays were used to analyze 130 unique breast cancer samples from as many patients and 23 technical duplicates. In addition 11 “Normal” samples from healthy breast tissue obtained from mammoplasty are included, as well as a collection of 14 breast cancer cell lines. Data production involved different array batches and hybridation series which were accounted for in the pre-processing of the data.

ORGANISM(S): Homo sapiens

SUBMITTER: Thierry Dubois 

PROVIDER: E-GEOD-65194 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is currently available for the treatment of patients with TNBC. In order to discover potential therapeutic targets, we searched for protein kinases that are overexpressed in human TNBC biopsies and whose silencing in TNBC cell lines causes cell death. A cohort including human BC biopsies obtained at Institut Curie as well as normal tissues h  ...[more]

PMID: 23700430

Publication: 1/3

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