RAI2 overexpression in MDA-MB231
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Benedikt Brors
PROVIDER: E-GEOD-65489 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.
Werner Stefan S Brors Benedikt B Eick Julia J Marques Elsa E Pogenberg Vivian V Parret Annabel A Kemming Dirk D Wood Antony W AW Edgren Henrik H Neubauer Hans H Streichert Thomas T Riethdorf Sabine S Bedi Upasana U Baccelli Irène I Jücker Manfred M Eils Roland R Fehm Tanja T Trumpp Andreas A Johnsen Steven A SA Klefström Juha J Wilmanns Matthias M Müller Volkmar V Pantel Klaus K Wikman Harriet H
Cancer discovery 20150225 5
<h4>Unlabelled</h4>Regulatory pathways that drive early hematogenous dissemination of tumor cells are insufficiently defined. Here, we used the presence of disseminated tumor cells (DTC) in the bone marrow to define patients with early disseminated breast cancer and identified low retinoic acid-induced 2 (RAI2) expression to be significantly associated with DTC status. Low RAI2 expression was also shown to be an independent poor prognostic factor in 10 different cancer datasets. Depletion of RAI ...[more]
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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
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