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Emergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Adam Gower

PROVIDER: E-GEOD-66078 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

Wilson Andrew A AA Ying Lei L Liesa Marc M Segeritz Charis-Patricia CP Mills Jason A JA Shen Steven S SS Jean Jyhchang J Lonza Geordie C GC Liberti Derek C DC Lang Alex H AH Nazaire Jean J Gower Adam C AC Müeller Franz-Josef FJ Mehta Pankaj P Ordóñez Adriana A Lomas David A DA Vallier Ludovic L Murphy George J GJ Mostoslavsky Gustavo G Spira Avrum A Shirihai Orian S OS Ramirez Maria I MI Gadue Paul P Kotton Darrell N DN

Stem cell reports 20150402 5

Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased versus normal human cohorts as they emerge during in vitro directed differentiation. Using iPSCs generated from a cohort carrying mutations (PiZZ) in the gene responsible for alpha-1 antitrypsin (AAT) deficiency, we find that the global transcriptomes of Pi ...[more]

PMID: 25843048

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Emergence of a developmental stage-dependent human liver disease signature demonstrated by directed differentiation of alpha-1 antitrypsin deficient iPS cells [HumanMethylation450]

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