Frequent derepression of the mesenchymal transcription factor gene in acute myeloid leukemia
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tim Somervaille
PROVIDER: E-GEOD-66256 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.
Somerville Tim D D TD Wiseman Daniel H DH Spencer Gary J GJ Huang Xu X Lynch James T JT Leong Hui Sun HS Williams Emma L EL Cheesman Edmund E Somervaille Tim C P TC
Cancer cell 20150901 3
Through in silico and other analyses, we identified FOXC1 as expressed in at least 20% of human AML cases, but not in normal hematopoietic populations. FOXC1 expression in AML was almost exclusively associated with expression of the HOXA/B locus. Functional experiments demonstrated that FOXC1 contributes to a block in monocyte/macrophage differentiation and enhances clonogenic potential. In in vivo analyses, FOXC1 collaborates with HOXA9 to accelerate significantly the onset of symptomatic leuke ...[more]
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