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Cell of origin strongly influences genetic selection in a mouse model of T-ALL.

ABSTRACT: Thymic lymphomas were generated by inducing Sleeping Beauty transposon mutagenesis at different stages of T-cell development. This dataset includes exon array results from 14 tumor samples from two different Sleeping Beauty models of T-ALL (7 Vav-SB and 7 CD4-SB samples).

ORGANISM(S): Mus musculus

SUBMITTER: Adam Dupuy

PROVIDER: E-GEOD-29849 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cell of origin strongly influences genetic selection in a mouse model of T-ALL.

Berquam-Vrieze Katherine E KE Nannapaneni Kishore K Brett Benjamin T BT Holmfeldt Linda L Ma Jing J Zagorodna Oksana O Jenkins Nancy A NA Copeland Neal G NG Meyerholz David K DK Knudson C Michael CM Mullighan Charles G CG Scheetz Todd E TE Dupuy Adam J AJ

Blood 20110809 17

Identifying the normal cell from which a tumor originates is crucial to understanding the etiology of that cancer. However, retrospective identification of the cell of origin in cancer is challenging because of the accumulation of genetic and epigenetic changes in tumor cells. The biologic state of the cell of origin likely influences the genetic events that drive transformation. We directly tested this hypothesis by performing a Sleeping Beauty transposon mutagenesis screen in which common inse ...[more]

PMID: 21828136

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