Early dendritic cell molecular signature modelling predicts late vaccine-induced adaptive T-cell responses (Illumina)
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ABSTRACT: Mice were vaccinated with different Lentivirus vector-plaforms or PBS. Transcriptomes of sorted dendritic cells 6 hours after vaccination were used to build a model predictive of the vector-platform efficacy measured as the antigen-specific response 5, 7 and 10 days after the vaccination Groups of 7-week-old female C57BL/6 mice (Charles River, France and Germany) were immunized either intravenously or sub-cutaneously with a controlled quantity of vector particles as defined in CompuVac assay protocols (www.compuvac.eu). Control mice were injected with 100 µL of phosphate buffered saline solution (PBS).
ORGANISM(S): Mus musculus
SUBMITTER: Nicolas Dérian
PROVIDER: E-GEOD-66797 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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