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Early dendritic cell molecular signature modelling predicts late vaccine-induced adaptive T-cell responses (Illumina)

ABSTRACT: Mice were vaccinated with different Lentivirus vector-plaforms or PBS. Transcriptomes of sorted dendritic cells 6 hours after vaccination were used to build a model predictive of the vector-platform efficacy measured as the antigen-specific response 5, 7 and 10 days after the vaccination

ORGANISM(S): Mus musculus

PROVIDER: GSE66797 | GEO | 2015/06/30

SECONDARY ACCESSION(S): PRJNA278648

REPOSITORIES: GEO

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Early dendritic cell molecular signature modelling predicts late vaccine-induced adaptive T-cell responses (Illumina)

Project description:Mice were vaccinated with different Lentivirus vector-plaforms or PBS. Transcriptomes of sorted dendritic cells 6 hours after vaccination were used to build a model predictive of the vector-platform efficacy measured as the antigen-specific response 5, 7 and 10 days after the vaccination Groups of 7-week-old female C57BL/6 mice (Charles River, France and Germany) were immunized either intravenously or sub-cutaneously with a controlled quantity of vector particles as defined in CompuVac assay protocols (www.compuvac.eu). Control mice were injected with 100 µL of phosphate buffered saline solution (PBS).

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