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Analysis of skeletal muscle gene expression upon mouse hindlimb unloading and reloading

ABSTRACT: To investigate the molecular mechanisms governing the transition of skeletal muscle from atrophy to compensatory regeneration and hypertrophy, we employed a mouse model involving hindlimb unloading and subsequent reloading, conducting a comprehensive analysis of global gene expression using RNA-sequencing (RNA-seq). Gastrocnemius muscle samples were obtained from three groups: control mice, mice subjected to 10 days of hindlimb unloading-induced muscle atrophy, and mice reintroduced to normal cage activity for 1 day following the unloading period (reloading).

ORGANISM(S): Mus musculus

PROVIDER: GSE237099 | GEO | 2023/07/16

REPOSITORIES: GEO

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Muscle unloading and reloading

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