Unknown,Transcriptomics,Genomics,Proteomics

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Hindlimb suspension and reloading study


ABSTRACT: Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice, 14 days -Hindlimb suspension for 7 days -Hindlimb suspension for 7 days, and subsequent reloading for 1 day -Hindlimb suspension for 7 days, and subsequent reloading for 7 days

ORGANISM(S): Mus musculus

SUBMITTER: Christoph Däpp 

PROVIDER: E-GEOD-1293 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations.

Flück Martin M   Däpp Christoph C   Schmutz Silvia S   Wit Ernst E   Hoppeler Hans H  

Journal of applied physiology (Bethesda, Md. : 1985) 20050801 2


Reprogramming of gene expression has been recognized as a main instructive modality for the adjustments of tissues to various kinds of stress. The recent application of gene expression profiling has provided a powerful tool to elucidate the molecular pathways underlying such tissue remodeling. However, the biological interpretations of expression profiling results critically depend on normalization of transcript signals to mRNA standards before statistical evaluation. A hypothesis is proposed wh  ...[more]

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