Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse 3T3-L1 fibroblasts differentiation during adipogenesis

ABSTRACT: 3T3-L1 fibroblasts are a commonly used in vitro model for adipogenesis. When induced with hormones, they differentiate into mature fat cells. Here, microarrays were used to study 3T3-L1 adipose differentiation through time. Experiment Overall Design: 3T3-L1 fibroblasts were cultured in vitro and induced to differentiate using standard MDI protocol. At successive time-points, cells were collected, and processed for microarray analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Jon Cheung 

PROVIDER: E-GEOD-6794 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.

Cheung Kevin J KJ   Tzameli Iphigenia I   Pissios Pavlos P   Rovira Ilsa I   Gavrilova Oksana O   Ohtsubo Toshio T   Chen Zhu Z   Finkel Toren T   Flier Jeffrey S JS   Friedman Jeffrey M JM  

Cell metabolism 20070201 2

In an effort to identify novel candidate regulators of adipogenesis, gene profiling of differentiating 3T3-L1 preadipocytes was analyzed using a novel algorithm. We report here the characterization of xanthine oxidoreductase (XOR) as a novel regulator of adipogenesis. XOR lies downstream of C/EBPbeta and upstream of PPARgamma, in the cascade of factors that control adipogenesis, and it regulates PPARgamma activity. In vitro, knockdown of XOR inhibits adipogenesis and PPARgamma activity while con  ...[more]

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