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Transcription profiling of rat left ventricle treated with streptozotocin vs. controls

ABSTRACT: 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, heart obtained at 12 weeks (thus animals were diabetic for 4 weeks). Left vent of heart. Experiment Overall Design: Three control rats (normal heart #1, 2, 3) Experiment Overall Design: Three diabetic rats (diabetic heart #1, 2, 3)

ORGANISM(S): Rattus norvegicus

SUBMITTER: Erik -- van Lunteren

PROVIDER: E-GEOD-6880 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oxidoreductase, morphogenesis, extracellular matrix, and calcium ion-binding gene expression in streptozotocin-induced diabetic rat heart.

van Lunteren Erik E Moyer Michelle M

American journal of physiology. Endocrinology and metabolism 20070612 3

Diabetes has far-ranging effects on cardiac structure and function. Previous gene expression studies of the heart in animal models of type 1 diabetes concur that there is altered expression of genes involved in lipid and protein metabolism, but they diverge with regard to expression changes involving many other functional groups of genes of mechanistic importance in diabetes-induced cardiac dysfunction. To obtain additional information about these controversial areas, genome-wide expression was ...[more]

PMID: 17566115

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